Epigenetic modifications such as DNA methylation play a key role in regulating gene expression. Emerging evidence suggests ...
DNA phosphorothioate modification is a distinctive epigenetic alteration in which a non‐bridging oxygen atom within the DNA sugar-phosphate backbone is replaced by ...
Researchers showed that in C. elegans, the protein MBD-2 regulates genes through repressive histone marks rather than DNA ...
Researchers have discovered that a DNA modification called 5-formylcytosine (5fC) functions as an activating epigenetic switch that kick-starts genes in early embryonic development. This finding ...
Epigenetic modifications such as DNA methylation play a key role in regulating gene expression. Emerging evidence suggests ...
The Human Genome Project changed everything. A map of the entire human sequence of DNA was the starting point for an enormous number of discoveries, from disease genes to how humans evolved. But DNA ...
Researchers from the Perelman School of Medicine at the University of Pennsylvania have invented a new way to map specific DNA markings called 5-methylcytosine (5mC) which regulate gene expression and ...
A new study has created a map of DNA modification in two regions of the brain critical to learning, memory and emotional regulation. The map offers a benchmark for ensuring stem cell-based models ...
Epigenetics refer to DNA modifications that may affect phenotype but don’t alter the nucleotide sequence itself. Epigenetic changes can often be passed down generations, hence the Greek prefix “epi”, ...
A Japanese research team has demonstrated that the use of antisense oligonucleotides (ASOs) with modified bases and sugars can enhance the effectiveness of targeting diseases in the central nervous ...
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