Molecular docking studies represent a cornerstone in modern drug discovery by providing detailed insights into the specific interactions between bioactive compounds and target enzymes. This ...

3D structure of a melanoma cell derived by ion abrasion scanning electron microscopy [National Cancer Institute (NCI). Image created by Sriram Subramaniam, NCI] Researchers at Sanford Burnham Prebys ...

A team of scientists has uncovered a critical mechanism that could pave the way for safer and more effective obesity ...

Alpha macroglobulin (AM) protease inhibitors utilize a unique trapping mechanism that allows them to inhibit proteases of any catalytic class. The best-known AM protease inhibitor is A2M, a large ...

In our bones, specialized cells called osteoblasts are responsible for building up bone substance. A team of researchers has now identified an enzyme that controls the activity of osteoblasts. An ...

An effective treatment could be found for one of the most aggressive pediatric cancers, alveolar rhabdomyosarcoma (aRMS). These kinds of tumors, which develop mainly in skeletal muscle, are ...

Colorectal cancer is one of the most prevalent tumors and a leading cause of cancer-related mortality. Despite advances achieved in recent years, resistance to available treatments remains one of the ...

Lymphomas belong to the group of malignant diseases of the immune system and mainly affect the organs of the lymphatic system. Anaplastic large cell lymphoma (ALCL) belongs to the subgroup of ...

Please provide your email address to receive an email when new articles are posted on . The mechanisms governing immune-related adverse events resulting from checkpoint inhibition therapy for cancer ...

WEST LAFAYETTE, Ind. - Scientists can now turn on or off the enzymes responsible for processing starchy foods into sugars in the human digestive system, a finding they believe will allow them to ...

Grapefruit juice is more than a breakfast staple — it’s a potent enzyme inhibitor that can dramatically alter how certain drugs are metabolized. This article explores how a tiny structural difference ...