The team applied this method to mRNA/saRNA constructs from 1 to 10 kb and assessed pH ranges from 3 to 6. For all the RNA constructs, the J2 immunoblot signal—a marker for dsRNA strands—decreased with ...
As monoclonal antibody (mAb) titers increase to multi-gram-per-liter ranges, downstream purification is increasingly strained. Protein A affinity chromatography is the industry standard for initial ...
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