FiercePharma

Shire's intrathecally delivered candidate for Hunter syndrome gets FDA's Fast Track Designation

Rare disease specialist Shire ($SHPG) announced today that it has received Fast Track Designation from the FDA for a reformulated, intrathecally delivered version of ...
The New England Journal of Medicine

Intrathecal Administration of Amethopterin in Leukemic Encephalopathy of Young Adults

THE neurologic manifestations of Central-nervous-system involvement in acute leukemia have been very well described. 1–7 Although involvement of the brain is not rare 7,8 greater emphasis has been ...
ascopubs.org

Multicentric, open-label, single-arm phase II study with oral lapatinib in combination with oral capecitabine plus intrathecally administered liposomal cytarabine for the ...

Study CTKI258A2202: A multicenter, open-label phase II trial of dovitinib (TKI258) in FGFR1-amplified and nonamplified HER2-negative metastatic breast cancer. Background: Rationale: BC with meningeal ...