Researchers from the Icahn School of Medicine at Mount Sinai have introduced KiNet, an interactive web portal designed to explore kinase-substrate interactions in human cellular systems. These ...

New molecular insights into the link between hepatocellular carcinoma and intratumoral fibrosis could lead to better ...

CD25 expression has long been recognized as an adverse prognostic marker in acute leukemias including acute myeloid leukemia ...

Scientists reprogrammed two widely used “chemically induced proximity” systems in a recent chemical science paper. CIP systems are very simple: when a small molecule is added, two engineered protein ...

Scientists have attempted to bolster microglia in the Alzheimer’s brain by switching on TREM2 signaling, but so far, these efforts have met with little success. Might it work better to bypass TREM2 by ...

Clinically available KRAS inhibitors mainly target G12C, which is rare in PDAC and often acquires resistance. Oncogenic KRAS inactivates RB1 via CDK4/6, while RB1 mutation is rare. Thus, CDK4/6 ...

A team led by researchers at the University of Cologne has identified a protein called ANKIB1 that acts as a volume dial for the body’s frontline immune defenses, controlling how strongly cells ...