Phase I dose escalation of 131I-metaiodobenzylguanidine with autologous bone marrow support in refractory neuroblastoma. MOPP/ABV hybrid chemotherapy for advanced Hodgkin's disease significantly ...

Multiple randomized clinical trials and electronic health record studies now show that metformin, a widely used and well-established medication, significantly reduces the risk of developing long COVID ...

• Randomly assigning patients in a clinical quality registry combines the features of a prospective randomized trial with a large-scale clinical registry • Registry-based trials are less selective and ...

Anyone who’s read my stuff with any regularity is acutely aware of my disdain for the way many observational studies are conducted and interpreted in health and nutrition research, as well as my ...

There is widespread interest in programs aiming to reduce spending and improve health care quality among “superutilizers,” patients with very high use of health care services. The “hotspotting” ...

We conducted a pragmatic, nonblinded, noninferiority, randomized trial comparing antibiotic therapy (10-day course) with appendectomy in patients with appendicitis at 25 U.S. centers. The primary ...

Dose- and Schedule-Dependent Inhibition of the Mammalian Target of Rapamycin Pathway With Everolimus: A Phase I Tumor Pharmacodynamic Study in Patients With Advanced Solid Tumors In this multicenter, ...

Randomized controlled trials are the most reliable method available for testing new treatments. They have become the standard that pharmaceutical companies must meet for calculating and proving the ...