The GPCRact AI model goes beyond AlphaFold3 by predicting whether drugs functionally activate G-protein-coupled receptors through allosteric signaling.

A receptor involved in normal physiological processes may also drive breast cancer growth when overexpressed.

The ability to grow stem cell-derived biological tissues, such as skin and other organs, in the laboratory holds promise for applications in areas including wound healing and transplants. However, ...

Scientists are aiming to determine the composition and topology of physiological Ashwell-Morell receptor ligands. Their findings will help uncover the receptor's still-hidden secrets. After earning ...

In the ever changing biotherapeutics landscape, antibody-drug conjugates (ADCs) and monoclonal antibodies (mAbs) success ...

However, the measurement of sIL-2R is simple compared to the complex story behind this biomarker that has become so central to the study of immune-mediated disease. Why measure soluble interleukin-2 ...

Details and references regarding individual diseases are provided in the Supplementary Appendix. CIDP denotes chronic inflammatory demyelinating polyneuropathy, Covid-19 coronavirus disease 2019, and ...