Gut

Modulating the gut-reproductive tract axis: microbial influence on gynaecological cancer pathogenesis and treatment

The gut microbiota plays a crucial role in regulating host immunity, metabolism and inflammation, with accumulating evidence ...
gut.bmj

Alterations of gut microbiome in autoimmune hepatitis

Objective The significance of the liver-microbiome axis has been increasingly recognised as a major modulator of autoimmunity. The aim of this study was to take advantage of a large well-defined ...
gut.bmj

The HLF/IL-6/STAT3 feedforward circuit drives hepatic stellate cell activation to promote liver fibrosis

Correspondence to Hong-Yang Wang and Jin Ding, The International Cooperation Laboratory on Signal Transduction, Shanghai Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, 225 ...
gut.bmj

Non-pathogenic bacteria elicit a differential cytokine response by intestinal epithelial cell/leucocyte co-cultures

Dr S Blum, Department of Immunology, Nestlé Research Centre, Vers-Chez-les-Blanc, Ch-1000 Lausanne 26, Switzerland. Email: stephanie.blum-sperisen{at}rdls.nestle.com BACKGROUND AND AIM Intestinal ...
gut.bmj

Lifestyle factors for the prevention of inflammatory bowel disease

Objective To estimate the proportion of cases of Crohn’s disease (CD) and ulcerative colitis (UC) that could be prevented by modifiable lifestyle factors. Design In a prospective cohort study of US ...
gut.bmj

Disruption of tumour-associated macrophage trafficking by the osteopontin-induced colony-stimulating factor-1 signalling sensitises hepatocellular carcinoma to anti-PD-L1 blockade

Objective In the tumour microenvironment, critical drivers of immune escape include the oncogenic activity of the tumour cell-intrinsic osteopontin (OPN), the expression of programmed death ligand 1 ...
gut.bmj

Mortality in biopsy-confirmed nonalcoholic fatty liver disease: results from a nationwide cohort

Objective Population-based data are lacking regarding the risk of overall and cause-specific mortality across the complete histological spectrum of non-alcoholic fatty liver disease (NAFLD). Design ...
gut.bmj

IDDF2025-ABS-0356 Catenibacterium mitsuokai promotes hepatocellular carcinogenesis by binding to hepatocyte and generating quinolinic acid

2 Institute of Digestive Disease and the Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong ...
gut.bmj

Association between appendectomy and Parkinson’s disease from the UK Biobank

2 Henan Key Laboratory of Cerebrovascular Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China Correspondence to Dr Changhe Shi, Department of ...
gut.bmj

Prevalence of non-alcoholic fatty liver disease and advanced fibrosis in Hong Kong Chinese: a population study using proton-magnetic resonance spectroscopy and transient ...

1 Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China 2 Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China 3 Department of ...
gut.bmj

Dyspepsia and the microbiome: time to focus on the small intestine

3 School of Medicine, University of Queensland, Translational Research Institute, Woolloongabba, Queensland, Australia Correspondence to Dr Erin R Shanahan, Gastroenterology Research, Level 5, ...
gut.bmj

Anti-HBV DNA vaccination does not prevent relapse after discontinuation of analogues in the treatment of chronic hepatitis B: a randomised trial—ANRS HB02 VAC-ADN

Objective The antiviral efficacy of nucleos(t)ide analogues whose main limitation is relapse after discontinuation requires long-term therapy. To overcome the risk of relapse and virological ...