Terry Suk, B.Sc., Ph.D.
In trying to treat neuroinflammation, scientists need better ways to visualize microglia in the brains of living people. Current microglial PET tracers target the mitochondrial transporter TSPO, but ...
R47H is a rare variant in TREM2 that triples the risk of Alzheimer’s disease in heterozygous carriers. This knock-in rat model carries the R47H mutation in the rat Trem2 gene and a humanized Aβ ...
Professional Information Associate ProfessorMayo Clinic New PET Tracers Visualize Activated and Homeostatic Microglia 10 Feb 2026 ...
Mounting evidence links infections to a greater risk of dementia, and vaccination to neuroprotection. What underlies this relationship? In a preprint posted to Research Square on January 13, ...
To create this model, an adeno-associated viral (AAV) vector encoding human tau with the P301L mutation was injected into the ventricles of neonatal mice. At 6 months of age, Tau P301L-AAV mice ...
TAF15 first surprised scientists two years ago, when it, instead of its infamous inclusion-mate, FUS, was found to fold into amyloid filaments in people with a rare neuropathological form of ...
Humanized TREM2 mice were created in a two-step process: First, researchers generated transgenic mice that carry BACs containing the common variant of human TREM2, including its regulatory elements.
Species: Mouse Genes: SNCA Modification: SNCA: Transgenic Disease Relevance: Parkinson's Disease Strain Name: B6;DBA-Tg(Thy1-SNCA)61Ema Genetic Background: (C57BL/6 x DBA/2)F1 (strain of origin) ...
Clinical trials for Alzheimer’s and other neurodegenerative diseases are expensive and slow, in part because they cannot find enough participants. Of the 5 million people with Alzheimer’s in the ...
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