cirm.ca.gov

A CRISPR-engineered isogenic model of the 22q11.2 A-B syndromic deletion.

22q11.2 deletion syndrome, associated with congenital and neuropsychiatric anomalies, is the most common copy number variant (CNV)-associated syndrome. Patient-derived, induced pluripotent stem cell ...
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Loss of TJP1 disrupts gastrulation patterning and increases differentiation toward the germ cell lineage in human pluripotent stem cells.

Ivana Vasic, Ashley R G Libby, Annie Maslan, Emily A Bulger, David Zalazar, Martina Z Krakora Compagno, Aaron Streets, Kiichiro Tomoda, Shinya Yamanaka, Todd C McDevitt Biological patterning events ...
cirm.ca.gov

Molecular Signatures in Cortical Development.

The cerebral cortex, a brain structure that is responsible for higher-order cognitive functions, contains hundreds of distinct cell types distributed across dozens of anatomical and functional areas.
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Understanding human embryogenesis by building programmable stem cell-based models.

Stem cell-based embryo models provide an alternative system to study an elusive period of develop- ment. Programmed mouse embryo models have recently been gener- ated by activating two endogenous ...
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Lineage-resolved atlas of the developing human cortex.

The human neocortex is composed of diverse cell types(1) that are generated during development according to spatially and temporally organized programmes initiated by neural stem cells(2-5). Despite ...
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CIRM approves over $160M to support preclinical and clinical research, advances education opportunities and access to clinical trials

South San Francisco, CA, December 11, 2025 – The California Institute for Regenerative Medicine (CIRM) governing board today approved funding of over $160 million for 16 new research awards to develop ...
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CIRM invests more than $42 million in translational-stage research

South San Francisco, CA, Oct. 27, 2023– The California Institute for Regenerative Medicine (CIRM), the world’s largest institution dedicated to regenerative medicine, awarded $42.1 million to fund ...
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CIRM approves $73 million in awards for discovery research

South San Francisco, CA, September 25, 2025 – The California Institute for Regenerative Medicine (CIRM) has approved awarding more than $73 million across 23 grants to support discovery research ...
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CIRM Approves New and Updated Funding Programs, Awards $26.5 Million for Clinical Research and Development

South San Francisco, CA, March 27, 2025 — The California Institute for Regenerative Medicine (CIRM), one of the world’s largest institutions dedicated to regenerative medicine, approved new and ...
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CIRM Announces Recommendations from Strategic Allocation Framework

South San Francisco, CA, September 27, 2024 – The California Institute for Regenerative Medicine (CIRM), one of the world’s largest institutes dedicated to regenerative medicine, announced key ...
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CIRM funds clinical research in heart failure and cystic fibrosis, supports 10 new translational projects

South San Francisco, CA, May 30, 2024 – The California Institute for Regenerative Medicine (CIRM), one of the world’s largest institutions dedicated to regenerative medicine, has awarded $53 million ...
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CIRM awards $8 million to advance vision loss gene therapy to clinical trials

South San Francisco, CA, April 24, 2025 — The California Institute for Regenerative Medicine (CIRM), one of the world’s largest institutions dedicated to regenerative medicine, has approved awarding ...