WHO slams US-funded newborn vaccine trial as “unethical”

The World Health Organization on Friday released a formal statement blasting a US-funded vaccine trial as “unethical,” ...
AHA/ASA Journals

Criteria to Assess the Predictive and Clinical Utility of Novel Models, Biomarkers, and Tools for Risk of Cardiovascular Disease: A Scientific Statement From the American Heart ...

Risk prediction has been used in the primary prevention of cardiovascular disease for >3 decades. Contemporary cardiovascular risk assessment relies on multivariable models, which integrate ...
AHA/ASA Journals

Second- and Third-Generation BCR-ABL Tyrosine Kinase Inhibitors and the Risk of Pulmonary Arterial Hypertension: A Prevalent New-User Design

BACKGROUND: BCR-ABL tyrosine kinase inhibitors (TKIs) have been increasingly linked to pulmonary arterial hypertension (PAH) since 2009, although supporting evidence is limited. Our objective was to ...

Scientists harness nature's chirality bias to design series of complex mechanically interlocked molecules

In nature, molecules often show a strong preference for partnering with other molecules that share the same chirality or handedness. A behavior that is quite evident in the phenomenon known as ...
The Lancet

Pharmacotherapy for metabolic dysfunction-associated steatohepatitis: heart–liver co-management

Metabolic dysfunction-associated steatotic liver disease (MASLD) affects approximately 30% of adults, with about 30% of cases progressing to metabolic dysfunction-associated steatohepatitis (MASH), ...
Frontiers

Drug Discovery for Antimicrobial Resistance: From Target Discovery to Combination Design using experimental and AI approaches

Antimicrobial resistance (AMR) is diminishing the effectiveness of existing antibiotics and intensifying the need for discovery pipelines that are both ...