An international team of scientists has discovered that a small, low-abundance protein plays a surprisingly big role in ...

Researchers have identified a protein that links brain immune activity, metabolism, and amyloid clearance, suggesting a new ...

The Challenge: The CAFA 6 (Critical Assessment of Functional Annotation) competition requires predicting Gene Ontology (GO) terms for 224,309 proteins—a computationally intensive task demanding ...

You need protein throughout your life for growth, cell structure, muscle building, and more. Protein needs vary from person to person, but a general recommendation is that 10-35% of your calories come ...

Old Main, the signature building on the University of Arizona campus in Tucson, Arizona. Researchers from the University of Arizona have uncovered how a protein complex, known for regulating cell ...

A new active substance attacks a key protein in tumor cells, leading to complete degradation. In cell experiments, this caused cancer cells to lose their protection and die. The active substance was ...

Researchers have unveiled the intricate molecular mechanisms governing TCF/LEF-mediated transcription in the canonical Wnt pathway, identifying these proteins as promising therapeutic targets for ...

A ready-to-run multimodal dataset and processing code for protein function prediction in budding yeast (Saccharomyces cerevisiae). It ties together: Protein–protein interaction (PPI) network (STRING) ...

Proteins play a critical role in cellular function by interacting with other biomolecules; missense variants that cause loss of protein function can lead to a broad spectrum of genetic disorders.

For decades, scientists have relied on structure to understand protein function. Tools like AlphaFold have revolutionized how researchers predict and design folded proteins, allowing for new ...

The researchers discovered that the flexible beginning of the Y2 receptor (purple) forms various direct contacts with the hormone NPY (green). The sum of these contacts controls which signals are ...